Insight into the Double-Edged Role of Ferroptosis in Disease

• Published in: Biomolecules (Basel, Switzerland) Vol. 11; no. 12; p. 1790
• Main Authors: Zhang, Lei, Jia, Ruohan, Li, Huizhen, Yu, Huarun, Ren, Keke, Jia, Shuangshuang, Li, Yanzhang, Wang, Qun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.11.2021; MDPI
• Subjects: Alzheimer's disease; Apoptosis; Cancer therapies; Cell death; Digestive System Diseases - drug therapy; Digestive System Diseases - metabolism; Drug development; Enzymes; Ferroptosis; Ferroptosis - drug effects; Fibrosis; Gene Expression Regulation - drug effects; Gene Regulatory Networks - drug effects; Genes; Homeostasis; Humans; inducers; inhibitors; Kidney diseases; Kinases; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Liver diseases; Metabolism; Mitochondria; Molecular Targeted Therapy; Morphology; Movement disorders; Necroptosis; Nervous system; Nervous System Diseases - drug therapy; Nervous System Diseases - metabolism; Neurodegenerative diseases; Oxidative stress; Parkinson's disease; Pathogenesis; Prostate cancer; Proteins; Reactive oxygen species; Reactive Oxygen Species - metabolism; Respiratory system; Review; ROS; Systemic diseases; Urologic Diseases - drug therapy; Urologic Diseases - metabolism; inhibitors; ferroptosis; systemic diseases; inducers; ROS
• ISSN: 2218-273X; 2218-273X
• DOI: 10.3390/biom11121790

Ferroptosis, a newly described type of iron-dependent programmed cell death that is distinct from apoptosis, necroptosis, and other types of cell death, is involved in lipid peroxidation (LP), reactive oxygen species (ROS) production, and mitochondrial dysfunction. Accumulating evidence has highlighted vital roles for ferroptosis in multiple diseases, including acute kidney injury, cancer, hepatic fibrosis, Parkinson's disease, and Alzheimer's disease. Therefore, ferroptosis has become one of the research hotspots for disease treatment and attracted extensive attention in recent years. This review mainly summarizes the relationship between ferroptosis and various diseases classified by the system, including the urinary system, digestive system, respiratory system, nervous system. In addition, the role and molecular mechanism of multiple inhibitors and inducers for ferroptosis are further elucidated. A deeper understanding of the relationship between ferroptosis and multiple diseases may provide new strategies for researching diseases and drug development based on ferroptosis.