Sperm DNA Integrity and Male Fertility in Farm Animals: A Review

The accurate prediction of male fertility is of major economic importance in the animal breeding industry. However, the results of conventional semen analysis do not always correlate with field fertility outcomes. There is evidence to indicate that mammalian fertilization and subsequent embryo devel...

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Bibliographic Details
Published inFrontiers in veterinary science Vol. 7; p. 321
Main Authors Kumaresan, Arumugam, Das Gupta, Mohua, Datta, Tirtha Kumar, Morrell, Jane M.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 19.06.2020
Subjects
Animal and Dairy Science
Clinical Science
DNA integrity
epigenetic modifications
Husdjursvetenskap
Klinisk vetenskap
male infertility
prognostic value
sperm
Veterinary Science
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Summary:The accurate prediction of male fertility is of major economic importance in the animal breeding industry. However, the results of conventional semen analysis do not always correlate with field fertility outcomes. There is evidence to indicate that mammalian fertilization and subsequent embryo development depend, in part, on the inherent integrity of the sperm DNA. Understanding the complex packaging of mammalian sperm chromatin and assessment of DNA integrity could potentially provide a benchmark in clinical infertility. In the era of assisted reproduction, especially when in-vitro fertilization or gamete intrafallopian transfer or intracytoplasmic sperm injection is used, assessment of sperm DNA integrity is important because spermatozoa are not subjected to the selection process occurring naturally in the female reproductive tract. Although sperm DNA integrity testing measures a significant biological parameter, its precise role in the infertility evaluation in farm animals remains unclear. In this review, the earlier findings on sperm DNA integrity in relation to male fertility are compiled and analyzed. Furthermore, the causes and consequences of sperm DNA damage are described, together with a review of advances in methods for detection of sperm DNA damage, and the prognostic value of sperm DNA quality on male fertility.
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Reviewed by: Jose Manuel Ortiz-Rodriguez, University of Extremadura, Spain; Gemma Gaitskell-Phillips, University of Extremadura, Spain; Manuel Hidalgo, Universidad de Córdoba, Spain
This article was submitted to Animal Reproduction - Theriogenology, a section of the journal Frontiers in Veterinary Science
Edited by: Fernando J. Peña Vega, University of Extremadura, Spain
ISSN:2297-1769
2297-1769
DOI:10.3389/fvets.2020.00321