Ubiquitous mammalian-wide interspersed repeats (MIRs) are molecular fossils from the mesozoic era

Short interspersed elements (SINES) are ubiquitous in mammalian genomes. Remarkable variety of these repeats among placental orders indicates that most of them amplified in each lineage independently, following mammalian radiation. Here, we present an ancient family of repeats, whose sequence. diver...

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Bibliographic Details
Published inNucleic acids research Vol. 23; no. 1; pp. 170 - 175
Main Authors Jurka, Jerzy, Zietkiewicz, Ewa, Labuda, Damian
Format Journal Article
LanguageEnglish
Published England Oxford University Press 11.01.1995
Subjects
Animals
Base Sequence
Biological Evolution
Consensus Sequence
DNA - genetics
DNA Primers - genetics
Genome
Genome, Human
Humans
mammalia
Mammals - genetics
Molecular Sequence Data
Repetitive Sequences, Nucleic Acid
Sequence Alignment
Sequence Homology, Nucleic Acid
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Summary:Short interspersed elements (SINES) are ubiquitous in mammalian genomes. Remarkable variety of these repeats among placental orders indicates that most of them amplified in each lineage independently, following mammalian radiation. Here, we present an ancient family of repeats, whose sequence. divergence and common occurrence among placental mammals, marsupials and monotremes indicate their amplification during the Mesozoic era. They are called MlRs for abundant Mammalian-wide Interspersed Repeats. With approximately 120,000 copies still detectable in the human genome (0.2-0.3% DNA), MlRs represent a ‘fossilized’ record of a major genetic event preceding the radiation of placental orders.
Bibliography:ArticleID:23.1.170
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ark:/67375/HXZ-WFDJ7XVP-J
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ISSN:0305-1048
1362-4962
DOI:10.1093/nar/23.1.170