Boolean modeling identifies Greatwall/ MASTL as an important regulator in the AURKA network of neuroblastoma

• Published in: Cancer letters Vol. 371; no. 1; pp. 79 - 89
• Main Authors: Dahlhaus, Meike, Burkovski, Andre, Hertwig, Falk, Mussel, Christoph, Volland, Ruth, Fischer, Matthias, Debatin, Klaus-Michael, Kestler, Hans A, Beltinger, Christian
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.02.2016; Elsevier Limited
• Subjects: Adolescent; AURKA; Aurora Kinase A - genetics; Aurora Kinase A - metabolism; Boolean network; Cell adhesion & migration; Cell cycle; Child; Child, Preschool; Computer Simulation; Databases, Genetic; Enzyme Stability; Female; Gene Expression Profiling - methods; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Gene regulatory network; Gene Regulatory Networks; Genes; GWL/MASTL; Hematology, Oncology and Palliative Medicine; Humans; Infant; Infant, Newborn; Kinases; Male; Medical prognosis; Medical research; Microtubule-Associated Proteins - genetics; Microtubule-Associated Proteins - metabolism; Models, Genetic; N-Myc Proto-Oncogene Protein; Neuroblastoma; Neuroblastoma - enzymology; Neuroblastoma - genetics; Neuroblastoma - mortality; Neuroblastoma - pathology; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Oligonucleotide Array Sequence Analysis; Oncogene Proteins - genetics; Oncogene Proteins - metabolism; Phosphatase; Protein Phosphatase 2 - genetics; Protein Phosphatase 2 - metabolism; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Proteins; Signal Transduction; Survival Analysis; Young Adult; Gene regulatory network; Neuroblastoma; Boolean network; AURKA; GWL/ MASTL; GWL/MASTL
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2015.11.025

Highlights • First mathematical model of a regulatory network of AURKA in neuroblastoma. • Model simulations uncover GWL/ MASTL stabilizing AURKA. • Role of GWL/ MASTL in clinical neuroblastoma supported by GSEA and endpoint predictions. • In silico modeling thus useful for unraveling interactions in neuroblastoma.