Diagnosis and Management of Borderline Resectable Pancreatic Adenocarcinoma

Borderline resectable pancreatic cancer represents a subcategory of advanced cancer that is typically defined by limited involvement of the major mesenteric vasculature. Such involvement is associated with a high likelihood of microscopically incomplete resection if surgery is used as the primary th...

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Bibliographic Details
Published inHematology/oncology clinics of North America Vol. 29; no. 4; p. 727
Main Authors Schwarz, Lilian, Katz, Matthew Harold G
Format Journal Article
LanguageEnglish
Published United States 01.08.2015
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Pancreatic Ductal - diagnosis
Carcinoma, Pancreatic Ductal - surgery
Cholangiopancreatography, Magnetic Resonance
Endosonography
Humans
Neoadjuvant Therapy - methods
Neoplasm Invasiveness
Neoplasm Staging
Pancreatectomy - methods
Pancreatic Neoplasms - diagnosis
Pancreatic Neoplasms - surgery
Tomography, X-Ray Computed
Neoadjuvant therapy
Chemotherapy
Borderline resectable
Chemoradiation
Pancreatic cancer
Pancreatoduodenectomy
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Summary:Borderline resectable pancreatic cancer represents a subcategory of advanced cancer that is typically defined by limited involvement of the major mesenteric vasculature. Such involvement is associated with a high likelihood of microscopically incomplete resection if surgery is used as the primary therapeutic modality. Increasing data support the role of neoadjuvant therapy as part of multimodality management but there is no uniformly accepted standard of care. This review discusses, based on recent literature and the experience of the Pancreatic Tumor Study Group at The University of Texas MD Anderson Cancer Center, the classification, definition, diagnosis, and management of borderline resectable pancreatic cancer.
ISSN:1558-1977
DOI:10.1016/j.hoc.2015.04.004