Hypothalamic Actions of SIRT1 and SIRT6 on Energy Balance

Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, wit...

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Published inInternational journal of molecular sciences Vol. 22; no. 3; p. 1430
Main Authors Quiñones, Mar, Martínez-Grobas, Eva, Fernø, Johan, Pérez-Lois, Raquel, Seoane, Luisa María, Al Massadi, Omar
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 31.01.2021
MDPI
Subjects
adiposity
body weight
Energy
Energy balance
Food
food intake
Gastrointestinal surgery
Hormones
Hypothalamus
Metabolic response
Metabolism
Nervous system
Neurons
Neuropeptides
Obesity
Peptides
Review
SIRT1
SIRT1 protein
SIRT6
Sirtuins
Thermogenesis
Transcription factors
Weight control
body weight
adiposity
type 2 diabetes
SIRT6
energy balance
SIRT1
obesity
food intake
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Summary:Sirtuins are NAD+ dependent deacetylases that regulate a large number of physiological processes. These enzymes are highly conserved and act as energy sensors to coordinate different metabolic responses in a controlled manner. At present, seven mammalian sirtuins (SIRT 1-7) have been identified, with SIRT1 and SIRT6 shown to exert their metabolic actions in the hypothalamus, both with crucial roles in eliciting responses to dampen metabolic complications associated with obesity. Therefore, our aim is to compile the current understanding on the role of SIRT1 and SIRT6 in the hypothalamus, especially highlighting their actions on the control of energy balance.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22031430