Evaluation of the antioxidant capacity of synthesized coumarins

• Published in: International journal of molecular sciences Vol. 13; no. 6; pp. 7260 - 7270
• Main Authors: Vianna, Damiana R, Bubols, Guilherme, Meirelles, Gabriela, Silva, Bárbara V, da Rocha, Alessandra, Lanznaster, Maurício, Monserrat, José Maria, Garcia, Solange Cristina, von Poser, Gilsane, Eifler-Lima, Vera Lucia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.06.2012; Molecular Diversity Preservation International (MDPI)
• Subjects: antioxidant capacity; Antioxidants; Antioxidants - chemical synthesis; Antioxidants - chemistry; Cocoa; coumarins; cyclic voltammetry; DPPH; Electronic mail systems; Free radicals; Peroxides - chemistry; peroxyl radicals; Umbelliferones - chemical synthesis; Umbelliferones - chemistry; Voltammetry; Brazil; peroxyl radicals; DPPH; cyclic voltammetry; antioxidant capacity; coumarins
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms13067260

Coumarins are secondary metabolites that are widely distributed within the plant kingdom, some of which have been extensively studied for their antioxidant properties. The antioxidant activity of coumarins assayed in the present study was measured by different methods, namely the 1,1-diphenyl-2-picryl-hydrazyl (DPPH(•)) method, cyclic voltammetry and the antioxidant capacity against peroxyl radicals (ACAP) method. The 7,8-dihydroxy-4-methylcoumarin (LaSOM 78), 5-carboxy-7,8-dihydroxy-4-methylcoumarin (LaSOM 79), and 6,7-dihydroxycoumarin (Esculetin) compounds proved to be the most active, showing the highest capacity to deplete the DPPH radicals, the highest antioxidant capacity against peroxyl radicals, and the lowest values of potential oxidation.