Assessment of miR-98-5p, miR-152-3p, miR-326 and miR-4289 Expression as Biomarker for Prostate Cancer Diagnosis

Prostate cancer (PCa) is one of the most commonly diagnosed cancers worldwide, accounting for almost 1 in 5 new cancer diagnoses in the US alone. The current non-invasive biomarker prostate specific antigen (PSA) has lately been presented with many limitations, such as low specificity and often asso...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 20; no. 5; p. 1154
Main Authors Moya, Leire, Meijer, Jonelle, Schubert, Sarah, Matin, Farhana, Batra, Jyotsna
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 06.03.2019
MDPI
Subjects
Apoptosis
biomarker
Biomarkers
Biomedical materials
Cell differentiation
Cell proliferation
diagnosis
Gene expression
Genomic instability
Lung cancer
Lymphatic system
Medical prognosis
Melanoma
Metastasis
MicroRNAs
miRNA
miRNAs
Osteosarcoma
Patients
prognosis
Prostate cancer
Review
Australia
diagnosis
prostate cancer
miRNAs
biomarker
prognosis
Online AccessGet full text

Cover

More Information
Summary:Prostate cancer (PCa) is one of the most commonly diagnosed cancers worldwide, accounting for almost 1 in 5 new cancer diagnoses in the US alone. The current non-invasive biomarker prostate specific antigen (PSA) has lately been presented with many limitations, such as low specificity and often associated with over-diagnosis. The dysregulation of miRNAs in cancer has been widely reported and it has often been shown to be specific, sensitive and stable, suggesting miRNAs could be a potential specific biomarker for the disease. Previously, we identified four miRNAs that are significantly upregulated in plasma from PCa patients when compared to healthy controls: miR-98-5p, miR-152-3p, miR-326 and miR-4289. This panel showed high specificity and sensitivity in detecting PCa (area under the curve (AUC) = 0.88). To investigate the specificity of these miRNAs as biomarkers for PCa, we undertook an in depth analysis on these miRNAs in cancer from the existing literature and data. Additionally, we explored their prognostic value found in the literature when available. Most studies showed these miRNAs are downregulated in cancer and this is often associated with cancer progression and poorer overall survival rate. These results suggest our four miRNA signatures could potentially become a specific PCa diagnostic tool of which prognostic potential should also be explored.
Bibliography:These authors contributed equally to this work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20051154