Advances of Wnt Signalling Pathway in Colorectal Cancer

• Published in: Cells (Basel, Switzerland) Vol. 12; no. 3; p. 447
• Main Authors: Zhu, Yaoyao, Li, Xia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.01.2023; MDPI
• Subjects: Analysis; Cancer; cancer stem cells; Care and treatment; Cell cycle; Cellular signal transduction; Chemotherapy; Circadian rhythm; colitis-associated carcinoma; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - pathology; Diagnosis; Diet; Drug resistance; Epidemiology; Gene expression; Humans; Inflammatory diseases; invasion and metastasis; Kinases; Ligands; Metastases; Mutation; Patient outcomes; Phosphorylation; Physiology; Prevention; Prognosis; Proteins; Review; Signal transduction; Transcription factors; Tumors; Wnt protein; Wnt proteins; Wnt Signaling Pathway; Wnt signalling pathway; β-Catenin; China; colitis-associated carcinoma; Wnt signalling pathway; colorectal cancer; cancer stem cells; invasion and metastasis
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells12030447

Colorectal cancer (CRC) represents one of the most common cancers worldwide, with a high mortality rate despite the decreasing incidence and new diagnostic and therapeutic strategies. CRC arises from both epidemiologic and molecular backgrounds. In addition to hereditary factor and genetic mutations, the strongly varying incidence of CRC is closely linked to chronic inflammatory disorders of the intestine and terrible dietary habits. The Wnt signalling pathway is a complex regulatory network that is implicated in many CRC physiological processes, including cancer occurrence, development, prognosis, invasion, and metastasis. It is currently believed to include classical Wnt/β-catenin, Wnt/PCP, and Wnt/Ca . In this review, we summarise the recent mechanisms and potential regulators of the three branches of the Wnt signalling pathway in CRC.