An update of the Zenith endovascular graft for abdominal aortic aneurysms: Initial implantation and mid-term follow-up data

• Published in: Journal of Vascular Surgery Vol. 33; no. 2; pp. 157 - 164
• Main Authors: Greenberga, Roy K., Lawrence-Brownb, Michael, Bhandaria, Guru, Hartleyb, David, Stelterc, Wolf, Umscheidc, Tomas, Chuterd, Timothy, Ivanceve, Krassnador, Greenf, Richard, Hopkinsong, Brian, Semmensh, James, Ouriela, Ken
• Format: Book Review Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2001; Elsevier
• Subjects: Angioplasty - adverse effects; Angioplasty - instrumentation; Aortic Aneurysm, Abdominal - classification; Aortic Aneurysm, Abdominal - diagnostic imaging; Aortic Aneurysm, Abdominal - surgery; Biological and medical sciences; Blood Vessel Prosthesis - adverse effects; Blood Vessel Prosthesis - standards; Comorbidity; Diseases of the cardiovascular system; Follow-Up Studies; Humans; Medical sciences; Proportional Hazards Models; Prospective Studies; Prosthesis Design; Prosthesis Failure; Radiography; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects); Risk Factors; Severity of Illness Index; Stents - adverse effects; Stents - standards; Survival Analysis; Treatment Outcome; Human; Endoprosthesis; Aneurysm; Instrumentation therapy; Cardiovascular disease; Instrumental obliteration; Arterial disease; Vascular disease; Abdominal aorta; Treatment; Follow up study; Evolution; Technique; Aortic disease
• ISSN: 0741-5214; 1097-6809
• DOI: 10.1067/mva.2001.111683

Purpose: To evaluate the initial and mid-term results of the Zenith endovascular grafting system for infrarenal abdominal aortic aneurysms. Methods: Prospective databases at seven centers were used to assess a cohort of patients that underwent treatment for aortic, aortoiliac, or iliac aneurysms since 1995. Data were analyzed to yield descriptive characteristics that pertained to the patients, the aortic morphologic features, the graft configuration, and the complications. Follow-up imaging data were used to determine size changes of the aneurysm sac, endoleak rates, and further complications. Finally survival data were expressed with a Kaplan-Meier analysis. Results: A total of 528 patients were treated with the Zenith endograft. Most of the patients (66%) were considered to be at a high physiologic risk for open repair. Successful graft implantation was accomplished in all but four patients. An overall endoleak rate of 15% was noted, of which 4% was treated urgently because they were thought to represent attachment site faults. The mean follow-up period was 18 months. A total of eight endograft migrations were detected after 2 years of follow-up with an early version of the system. There were three late conversions; two ruptures occurred during the follow-up period. Conclusion: This early and mid-term data support the use of the Zenith endovascular graft for the treatment of aortic and aortoiliac aneurysms in properly selected patients. The risks of significant complications or aneurysm rupture are low. (J Vasc Surg 2001;33:S157-64.)