Macrophage Phenotype and Fibrosis in Diabetic Nephropathy

• Published in: International journal of molecular sciences Vol. 21; no. 8; p. 2806
• Main Authors: Calle, Priscila, Hotter, Georgina
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 17.04.2020; MDPI
• Subjects: Accumulation; Animals; Biopsy; Cell growth; Cell Polarity; Chemokines; Collagen; Creatinine; Cytokines; Diabetes; Diabetes mellitus; Diabetic Nephropathies - immunology; Diabetic Nephropathies - pathology; Diabetic nephropathy; End-stage renal disease; Extracellular matrix; Fibrosis; Genotype & phenotype; Growth factors; Humans; Hyperglycemia; Inflammation; Kidney - immunology; Kidney - pathology; Kidney diseases; Macrophages; Macrophages - metabolism; Nephropathy; Oxidative Stress; Phenotype; Phenotypes; Phenotypic plasticity; Polarization; Renal function; Review; Tumor necrosis factor-TNF; Wound healing; macrophages; fibrosis; diabetic nephropathy
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21082806

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease globally. The primary initiating mechanism in DN is hyperglycemia-induced vascular dysfunction, but its progression is due to different pathological mechanisms, including oxidative stress, inflammatory cells infiltration, inflammation and fibrosis. Macrophages (Mφ) accumulation in kidneys correlates strongly with serum creatinine, interstitial myofibroblast accumulation and interstitial fibrosis scores. However, whether or not Mφ polarization is involved in the progression of DN has not been adequately defined. The prevalence of the different phenotypes during the course of DN, the existence of hybrid phenotypes and the plasticity of these cells depending of the environment have led to inconclusive results. In the same sense the role of the different macrophage phenotype in fibrosis associated or not to DN warrants additional investigation into Mφ polarization and its role in fibrosis. Due to the association between fibrosis and the progressive decline of renal function in DN, and the role of the different phenotypes of Mφ in fibrosis, in this review we examine the role of macrophage phenotype control in DN and highlight the potential factors contributing to phenotype change and injury or repair in DN.