Plasmodium vivax metacaspase 1 (PvMCA1) catalytic domain is conserved in field isolates from Brazilian Amazon
In the present study, we investigated the genetic diversity of Plasmodium vivax metacaspase 1 ( Pv MCA1) catalytic domain in two municipalities of the main malaria hotspot in Brazil, i.e., the Juruá Valley, and observed complete sequence identity among all P. vivax field isolates and the Sal-1 refer...
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Published in | Memórias do Instituto Oswaldo Cruz Vol. 116; p. e200584 |
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Main Authors | , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
Instituto Oswaldo Cruz, Ministério da Saúde
01.01.2021
Fundação Oswaldo Cruz (FIOCRUZ) |
Subjects | |
Online Access | Get full text |
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Summary: | In the present study, we investigated the genetic diversity of
Plasmodium vivax
metacaspase 1 (
Pv
MCA1) catalytic domain in two municipalities of the main malaria hotspot in Brazil, i.e., the Juruá Valley, and observed complete sequence identity among all
P. vivax
field isolates and the Sal-1 reference strain. Analysis of
Pv
MCA1 catalytic domain in different
P. vivax
genomic sequences publicly available also revealed a high degree of conservation worldwide, with very few amino acid substitutions that were not related to putative histidine and cysteine catalytic residues, whose involvement with the active site of protease was herein predicted by molecular modeling. The genetic conservation presented by
Pv
MCA1 may contribute to its eligibility as a druggable target candidate in vivax malaria. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Conceptualisation - HASS and PRRT; investigation and methodology - HASS, VFE, CMB, BOB, JPB and EKPR; formal analysis - ABMR, ACRG, FFM and JHMS; resources - GCM, MVGL, RMS, JCLJ, CTDR, LRPR and PRRT; writing - original draft preparation - HAS and PRRT; writing - review and editing - MVGL, CTDR, LRPR and PRRT; supervision - PRRT. |
ISSN: | 0074-0276 1678-8060 1678-8060 |
DOI: | 10.1590/0074-02760200584 |