Prevalence and determinants of diabetic polyneuropathy in a sub-Saharan African referral hospital

• Published in: Journal of the neurological sciences Vol. 355; no. 1; pp. 108 - 112
• Main Authors: Kuate-Tegueu, C, Temfack, E, Ngankou, S, Doumbe, J, Djientcheu, V.P, Kengne, A.P
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.08.2015
• Subjects: Africa; Aged; Cameroon; Cameroon - epidemiology; Cross-Sectional Studies; Diabetes mellitus; Diabetic Neuropathies - diagnosis; Diabetic Neuropathies - epidemiology; Diabetic neuropathy; Female; Humans; Male; Middle Aged; Neurology; Painful diabetic neuropathy; Polyneuropathy; Prevalence; Referral and Consultation - statistics & numerical data; Regression Analysis; Risk factors; Cameroon; Cameroon; Prevalence; Diabetes mellitus; Africa; Diabetic neuropathy; Polyneuropathy; Painful diabetic neuropathy; Risk factors
• ISSN: 0022-510X; 1878-5883
• DOI: 10.1016/j.jns.2015.05.035

Abstract Background Diabetic peripheral neuropathy is the commonest complication of diabetes mellitus, and a major cause of limb amputations. In general however, the magnitude of diabetic neuropathy in sub-Saharan Africans with diabetes has been less reliably quantified. We assessed the prevalence and determinants of diabetic polyneuropathy in hospital settings in Cameroon. Methods We conducted a cross-sectional survey at the Douala Laquintinie Hospital, which is one of the main reference hospital in the economic capital of Cameroon (3 million populations). Participants included all patients with type 1 (T1DM) or type 2 (T2DM) diabetes who reported to the hospital regardless of the reason, during a 5-month recruitment period. Polyneuropathy was defined as diabetic in a patient with a Diabetic Neuropathy Examination score of > 3/16 and/or a monofilament score of < 5/9. Results A total of 306 patients were recruited, including 196 women (64%) and 294 (96%) with T2DM. The mean (standard deviation) values were 59.8 (11.2) years for age and 8.4 (8.2) years for diabetes duration. Clinical signs of polyneuropathy were present in 102 (crude prevalence rate: 33.3%) patients. The polyneuropathy was symptomatic in 79/102 (77.4%) patients. Determinants of polyneuropathy were urban residence (p = 0.02), infection with hepatitis C virus (p = 0.002), infection with HIV (p = 0.012) and presence of albuminuria (p = 0.0001). Conclusion About one in three patients with diabetes reporting to the hospital in our setting has prevalent diabetes related polyneuropathy. This emphasizes the importance of routine implementation of therapeutic education and other measures to limit the complications.