The Roles of Lipoprotein in Psoriasis

• Published in: International journal of molecular sciences Vol. 21; no. 3; p. 859
• Main Authors: Shih, Chun-Ming, Chen, Chang-Cyuan, Chu, Chen-Kuo, Wang, Kuo-Hsien, Huang, Chun-Yao, Lee, Ai-Wei
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.01.2020; MDPI
• Subjects: Adhesion; Antigens; Atherogenesis; Atherosclerosis; Blood vessels; Cardiovascular diseases; Cell adhesion molecules; Chemokines; Cholesterol; Cytokines; Dendritic cells; Dermis; Diabetes mellitus; Disease; Endothelial cells; Endothelium; Epidemiology; Hyperlipidemia; Hyperplasia; Immune system; Immunology; Inflammation; Intercellular adhesion molecule 1; Kinases; Leukocytes (mononuclear); lipid; Lipids; Lipoproteins; Low density lipoprotein; Lymphocytes; Macrophages; Myocardial infarction; Osmosis; Psoriasis; Review; Risk analysis; Risk factors; Skin; Skin diseases; Transcription factors; Tumor necrosis factor-TNF; Vascular cell adhesion molecule 1; Vascular endothelial growth factor; inflammation; lipid; psoriasis
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms21030859

The association between psoriasis and cardiovascular disease risk has been supported by recent epidemiological data. Patients with psoriasis have an increased adjusted relative risk for myocardial infarction. As such, the cardiovascular risk conferred by severe psoriasis may be comparable to what is seen with other well-established risk factors, such as diabetes mellitus. Previous studies demonstrated that low-density lipoprotein (LDL) plays critical roles during atherogenesis. It may be caused by the accumulation of macrophages and lipoprotein in the vessel wall. Oxidized LDL (ox-LDL) stimulates the expression of adhesion molecules, such as ICAM-1 and VCAM-1, on endothelial cells and increases the attachment of mononuclear cells and the endothelium. Even though previous evidence demonstrated that psoriasis patients have tortuous and dilated blood vessels in the dermis, which results in the leakage of ox-LDL, the leaked ox-LDL may increase the expression of adhesion molecules and cytokines, and disturb the static balance of osmosis. Therefore, exploration of the relationship between hyperlipidemia and psoriasis may be another novel treatment option for psoriasis and may represent the most promising strategy.