Characteristic Features on Morphologic and Topographic Findings of Pulmonary Vein Orifices in Transition From Diastolic Dysfunction to Heart Failure: A Computerized Tomography Study

• Published in: Journal of cardiac failure Vol. 22; no. 4; pp. 316 - 320
• Main Authors: Hung, Sho-Ting, Yun, Chun-Ho, Wu, Tung-Hsin, Yang, Fei-Shih, Kuo, Jen-Yuan, Hung, Chung-Lieh, Hou, Charles Jia-Yin, Chang, Shun-Chuan, Fares, Anas, Nshisso, Lemba Dina, Cury, Ricardo C., Yeh, Hung-I., Bezerra, Hiram G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2016
• Subjects: Adult; Aged; Cardiovascular; Cohort Studies; Cross-Sectional Studies; Diastolic dysfunction; Disease Progression; Female; Heart Failure - diagnostic imaging; Heart Failure - physiopathology; heart failure with preserved ejection fraction (HFpEF); Humans; Male; Middle Aged; orifice areas; pulmonary vein; Pulmonary Veins - diagnostic imaging; Pulmonary Veins - physiopathology; Retrospective Studies; Tomography, X-Ray Computed; Ventricular Dysfunction, Left - diagnostic imaging; Ventricular Dysfunction, Left - physiopathology; Diastolic dysfunction; pulmonary vein; heart failure with preserved ejection fraction (HFpEF); orifice areas
• ISSN: 1071-9164; 1532-8414; 1532-8414
• DOI: 10.1016/j.cardfail.2015.12.019

•Morphologic descriptions of PVs in transition from DD to HF have been lacking.•We observed a graded enlargement of PV orifice areas from DD to HF.•Maximum LSPV and LIPV areas significantly increased clinical diagnosis of HFpEF.•CT-based PV measurements may help to identify subjects at risk for HF. Diastolic dysfunction (DD), a precursor to clinical heart failure (HF), has traditionally been evaluated by means of echocardiography. Data regarding morphologic descriptions of pulmonary vein (PV) orifices in transition from DD to HF have been lacking. We retrospectively studied 124 subjects with computerized tomography (CT)–derived PV parameters and echocardiography-derived diastolic indices. We categorized our subjects as 1) non-DD, 2) DD, or 3) heart failure with preserved ejection fraction (HFpEF) and observed a graded enlargement for 4 PV orifice areas across these groups. Positive linear relationship between the 4 PV orifice areas, echocardiography-derived mean pulmonary capillary wedge pressure (PCWP), and velocity of propagation (VP) were observed. Finally, maximum areas of left superior pulmonary vein (LSPV) and left inferior pulmonary vein (LIPV) significantly increased clinical diagnosis of HFpEF (likelihood-ratio χ2: from 42.92 to 50.75 and 54.67 for LSPV and LIPV, respectively) when superimposed on left ventricular mass index, PCWP, and left atrial volume. PV size measurements with the use of CT are feasible and further aid in diseases discrimination between preclinical DD and those progressed into HF, even with preserved global pumping. Our data suggest that CT-based PV measures may help to identify subjects at risk for HF.