MeCP2 and Chromatin Compartmentalization

Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Ret...

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Bibliographic Details
Published inCells (Basel, Switzerland) Vol. 9; no. 4; p. 878
Main Authors Schmidt, Annika, Zhang, Hui, Cardoso, M Cristina
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 03.04.2020
MDPI
Subjects
Amino acids
Animals
Binding sites
Brain
Chromatin
Chromatin - metabolism
CpG islands
Deoxyribonucleic acid
DNA
DNA methylation
DNA methylation readers
DNA modifications
Gene expression
Gene regulation
Genomes
heterochromatin
higher order chromatin structure
Humans
Isoforms
MeCP2
MeCP2 protein
Methyl-CpG binding protein
Methyl-CpG-Binding Protein 2 - genetics
Methyl-CpG-Binding Protein 2 - metabolism
Models, Biological
Mutation
Oxidation
Protein Binding
Protein Processing, Post-Translational
Proteins
Rett syndrome
Rett Syndrome - genetics
Review
Stem cells
Transcription
MeCP2
DNA methylation readers
higher order chromatin structure
DNA modifications
Rett syndrome
heterochromatin
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Summary:Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
They are first authors.
ISSN:2073-4409
2073-4409
DOI:10.3390/cells9040878