Structural and Functional Remodeling of Mitochondria in Cardiac Diseases

Mitochondria undergo structural and functional remodeling to meet the cell demand in response to the intracellular and extracellular stimulations, playing an essential role in maintaining normal cellular function. Merging evidence demonstrated that dysregulation of mitochondrial remodeling is a fund...

Full description

Saved in:
Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 8; p. 4167
Main Authors Sun, Xiaonan, Alford, Jalen, Qiu, Hongyu
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 17.04.2021
MDPI
Subjects
Adenosine triphosphate
Animals
Biosynthesis
Cardiomyocytes
Coronary artery disease
Gene expression
Genomes
Heart
heart disease
Heart diseases
Heart Diseases - metabolism
heart failure
Homeostasis
Humans
Kinases
Metabolism
Mitochondria
mitochondria remodeling
Mitochondria, Heart - metabolism
Mitochondria, Heart - ultrastructure
Mitochondrial DNA
Mitochondrial Dynamics
Morphology
Mutation
Oxidative Stress
Pathogenesis
Polymerization
Proteins
Review
Structure-function relationships
heart failure
mitochondria remodeling
metabolism
heart disease
Online AccessGet full text

Cover

More Information
Summary:Mitochondria undergo structural and functional remodeling to meet the cell demand in response to the intracellular and extracellular stimulations, playing an essential role in maintaining normal cellular function. Merging evidence demonstrated that dysregulation of mitochondrial remodeling is a fundamental driving force of complex human diseases, highlighting its crucial pathophysiological roles and therapeutic potential. In this review, we outlined the progress of the molecular basis of mitochondrial structural and functional remodeling and their regulatory network. In particular, we summarized the latest evidence of the fundamental association of impaired mitochondrial remodeling in developing diverse cardiac diseases and the underlying mechanisms. We also explored the therapeutic potential related to mitochondrial remodeling and future research direction. This updated information would improve our knowledge of mitochondrial biology and cardiac diseases' pathogenesis, which would inspire new potential strategies for treating these diseases by targeting mitochondria remodeling.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22084167