The Regulatory Role of KIBRA and PTPN14 in Hippo Signaling and Beyond

The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal effectors of this pathway are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to the development of cancer. Complex networks o...

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Published inGenes Vol. 7; no. 6; p. 23
Main Authors Wilson, Kayla E, Yang, Nuo, Mussell, Ashley L, Zhang, Jianmin
Format Journal Article Book Review
LanguageEnglish
Published Switzerland MDPI AG 27.05.2016
MDPI
Subjects
Hippo signaling pathway
KIBRA
PTPN14
Review
KIBRA
Hippo signaling pathway
PTPN14
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Summary:The Hippo signaling pathway regulates cellular proliferation and survival, thus exerting profound effects on normal cell fate and tumorigenesis. Pivotal effectors of this pathway are YAP/TAZ, transcriptional co-activators whose dysfunction contributes to the development of cancer. Complex networks of intracellular and extracellular signaling pathways that modulate YAP and TAZ activities have recently been identified. Among them, KIBRA and PTPN14 are two evolutionarily-conserved and important YAP/TAZ upstream regulators. They can negatively regulate YAP/TAZ functions separately or in concert. In this review, we summarize the current and emerging regulatory roles of KIBRA and PTPN14 in the Hippo pathway and their functions in cancer.
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ISSN:2073-4425
2073-4425
DOI:10.3390/genes7060023