Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

• Published in: International journal of molecular sciences Vol. 20; no. 2; p. 341
• Main Authors: Ma, Dik-Lung, Wu, Chun, Cheng, Sha-Sha, Lee, Fu-Wa, Han, Quan-Bin, Leung, Chung-Hang
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.01.2019; MDPI
• Subjects: Binding; Biocompatibility; Bone marrow; Cancer; Cancer therapies; cancer therapy; Carboplatin; Chloride; Cisplatin; Cobalt; Configurations; cytotoxicity; Deoxyribonucleic acid; DNA; Drug resistance; Drugs; Efficiency; Grooves; Hydrophobicity; Kinases; Ligands; natural product; Natural products; Osmium; Oxaliplatin; Palladium; Platinum; Prostate cancer; Review; Ruthenium; Ruthenium compounds; Selectivity; Sodium chloride; Toxicity; transition metal complex; Tumor necrosis factor-TNF; Tumors; transition metal complex; cancer therapy; natural product; cytotoxicity
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms20020341

Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.