Plasmonic Gold Nanoisland Film for Bacterial Theranostics

• Published in: Nanomaterials (Basel, Switzerland) Vol. 11; no. 11; p. 3139
• Main Authors: Tan, Shih-Hua, Yougbaré, Sibidou, Tao, Hsuan-Ya, Chang, Che-Chang, Kuo, Tsung-Rong
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.11.2021; MDPI
• Subjects: Cancer; Dengue fever; detection; E coli; Escherichia coli; Glass substrates; Gold; gold nanoisland film; Irradiation; Nanomaterials; Nanotechnology; photothermal therapy; Plasmonics; Precision medicine; Raman spectra; Scanning electron microscopy; Substrates; surface-enhanced Raman scattering; Sustainability; theranostics; Therapy; Ultraviolet spectra; Visible spectrum; X-ray spectroscopy; Zika virus; Canada; United States > US; theranostics; detection; surface-enhanced Raman scattering; photothermal therapy; gold nanoisland film
• ISSN: 2079-4991; 2079-4991
• DOI: 10.3390/nano11113139

Plasmonic nanomaterials have been intensively explored for applications in biomedical detection and therapy for human sustainability. Herein, plasmonic gold nanoisland (NI) film (AuNIF) was fabricated onto a glass substrate by a facile seed-mediated growth approach. The structure of the tortuous gold NIs of the AuNIF was demonstrated by scanning electron microscopy and energy-dispersive X-ray spectroscopy. Based on the ultraviolet-visible spectrum, the AuNIF revealed plasmonic absorption with maximum intensity at 624 nm. With the change to the surface topography created by the NIs, the capture efficiency of ( ) by the AuNIF was significantly increased compared to that of the glass substrate. The AuNIF was applied as a surface-enhanced Raman scattering (SERS) substrate to enhance the Raman signal of . Moreover, the plasmonic AuNIF exhibited a superior photothermal effect under irradiation with simulated AM1.5 sunlight. For photothermal therapy, the AuNIF also displayed outstanding efficiency in the photothermal killing of . Using a combination of SERS detection and photothermal therapy, the AuNIF could be a promising platform for bacterial theranostics.