Why do peroxisomes associate with the cytoskeleton?

Attachment of peroxisomes to cytoskeleton and movement along microtubular filaments and actin cables are essential and highly regulated processes enabling metabolic efficiency, biogenesis, maintenance and inheritance of this dynamic cellular compartment. Several peroxisome-associated proteins have b...

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Published inBiochimica et biophysica acta Vol. 1863; no. 5; pp. 1019 - 1026
Main Authors Neuhaus, Alexander, Eggeling, Christian, Erdmann, Ralf, Schliebs, Wolfgang
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.05.2016
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Summary:Attachment of peroxisomes to cytoskeleton and movement along microtubular filaments and actin cables are essential and highly regulated processes enabling metabolic efficiency, biogenesis, maintenance and inheritance of this dynamic cellular compartment. Several peroxisome-associated proteins have been identified, which mediate interaction with motor proteins, adaptor proteins or other constituents of the cytoskeleton. It appears that there is a species-specific complexity of protein–protein interactions required to control directional movement and arresting. An open question is why some proteins with a specific role in peroxisomal protein import have an additional function in the regulation of cytoskeleton binding and motility of peroxisomes. This article is part of a Special Issue entitled: Peroxisomes edited by Ralf Erdmann. •Cytoskeleton-based motility controls maintenance and function of peroxisomes.•Peroxisomes move along microtubules and actin cables via conserved mechanisms.•Structural basis of peroxisome–cytoskeleton interaction is species dependent.•Peroxins involved in protein import often determine cytoskeleton association.
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ISSN:0167-4889
0006-3002
1879-2596
DOI:10.1016/j.bbamcr.2015.11.022