Lemierre's syndrome due to Fusobacterium necrophorum

Summary We present a case of a patient with Lemierre's syndrome caused by Fusobacterium necrophorum who developed a right frontal lobe brain abscess. We summarise the epidemiology, microbiology, pathogenesis, clinical presentation, diagnosis, complications, therapy, and outcomes of Lemierre...

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Bibliographic Details
Published inThe Lancet infectious diseases Vol. 12; no. 10; pp. 808 - 815
Main Authors Kuppalli, Krutika, Dr, Livorsi, Daniel, MD, Talati, Naasha J, MD, Osborn, Melissa, MD
Format Journal Article
LanguageEnglish
Published London Elsevier Ltd 01.10.2012
Lancet Publishing Group
Elsevier Limited
Subjects
Adolescent
Anti-Bacterial Agents - therapeutic use
Bacterial diseases
Bacterial diseases of the nervous system. Bacterial myositis
Biological and medical sciences
Brain Abscess - diagnosis
Brain Abscess - drug therapy
Brain Abscess - microbiology
Epidemiology
Fusobacterium necrophorum
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Lemierre Syndrome - complications
Lemierre Syndrome - drug therapy
Lemierre Syndrome - microbiology
Magnetic Resonance Imaging
Male
Medical sciences
Microbiology
Pleural Effusion - complications
Human
Pathogenesis
Fusobacterium necrophorum
Bacteroidaceae
Cerebral disorder
Infection
Symptomatology
Lemierre syndrome
Treatment
Central nervous system disease
Bacteriosis
Brain abscess
Bacteria
Complication
Diagnosis
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Summary:Summary We present a case of a patient with Lemierre's syndrome caused by Fusobacterium necrophorum who developed a right frontal lobe brain abscess. We summarise the epidemiology, microbiology, pathogenesis, clinical presentation, diagnosis, complications, therapy, and outcomes of Lemierre's syndrome. F necrophorum is most commonly associated with Lemierre's syndrome: a septic thrombophlebitis of the internal jugular vein. Patients usually present with an exudative tonsillitis, sore throat, dysphagia, and unilateral neck pain. Diagnosis of septic thrombophlebitis is best confirmed by obtaining a CT scan of the neck with contrast. Complications of the disease include bacteraemia with septic abscesses to the lungs, joints, liver, peritoneum, kidneys, and brain. Treatment should include a prolonged course of intravenous beta-lactam antibiotic plus metronidazole.
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ISSN:1473-3099
1474-4457
DOI:10.1016/S1473-3099(12)70089-0