Safety Assessment of Dialkyl Sulfosuccinate Salts as Used in Cosmetics

• Published in: International journal of toxicology Vol. 35; no. 3 suppl; p. 34S
• Main Authors: Fiume, Monice M, Heldreth, Bart, Bergfeld, Wilma F, Belsito, Donald V, Hill, Ronald A, Klaassen, Curtis D, Liebler, Daniel C, Marks, Jr, James G, Shank, Ronald C, Slaga, Thomas J, Snyder, Paul W, Andersen, F Alan
• Format: Journal Article
• Language: English
• Published: United States 01.11.2016
• Subjects: Animals; Consumer Product Safety - legislation & jurisprudence; Cosmetics - chemistry; Cosmetics - standards; Dioctyl Sulfosuccinic Acid - chemistry; Dioctyl Sulfosuccinic Acid - pharmacokinetics; Dioctyl Sulfosuccinic Acid - toxicity; Humans; Molecular Structure; Structure-Activity Relationship; Surface-Active Agents - chemistry; Surface-Active Agents - pharmacokinetics; Surface-Active Agents - toxicity; Toxicity Tests - methods; Toxicokinetics; United States; United States Food and Drug Administration; safety; dialkyl sulfosuccinate salts; cosmetics
• ISSN: 1092-874X
• DOI: 10.1177/1091581816673808

The Cosmetic Ingredient Review (CIR) Expert Panel (Panel) assessed the safety of 8 dialkyl sulfosuccinate salts for use in cosmetics, finding that these ingredients are safe in cosmetics in the present practices of use and concentration when formulated to be nonirritating. The dialkyl sulfosuccinate salts primarily function as surfactants in cosmetics. The Panel reviewed the new and existing available animal and clinical data in making its determination of safety. The Panel found it appropriate to extrapolate the data on diethylhexyl sodium sulfosuccinate to assess the safety of the entire group because all of the diesters are of a similar alkyl chain length, all are symmetrically substituted, and all have similar functions in cosmetic formulations.