Investigation of Chemical Constituents of Eranthis longistipitata (Ranunculaceae): Coumarins and Furochromones

• Published in: International journal of molecular sciences Vol. 23; no. 1; p. 406
• Main Authors: Erst, Andrey S, Chernonosov, Alexander A, Petrova, Natalia V, Kulikovskiy, Maxim S, Maltseva, Svetlana Yu, Wang, Wei, Kostikova, Vera A
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 30.12.2021; MDPI
• Subjects: Aglycones; Alcohol; Biological activity; Catechin; chemical composition; Chromatography, Liquid; Chromones - analysis; Chromones - chemistry; coumarin; Coumarins - analysis; Coumarins - chemistry; Eranthis; Eranthis longistipitata; Ethanol; Fatty acids; Flavonoids; furochromone; Kaempferol; LC-HRMS; Leaves; Liquid chromatography; Mass Spectrometry; Mass spectroscopy; Metabolism; Metabolites; Methoxsalen; Phytochemicals; Phytochemicals - analysis; Phytochemicals - chemistry; Plant resistance; Population studies; Populations; Quercetin; Ranunculaceae; Ranunculaceae - chemistry; Scientific imaging; Visnagin; extract; furochromone; Ranunculaceae; coumarin; fatty acid; Eranthis longistipitata; LC-HRMS; chemical composition
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms23010406

Aqueous-ethanol extracts (70%) from the leaves of Regel. (Ranunculaceae Juss.)-collected from natural populations of Kyrgyzstan-were studied by liquid chromatography with high-resolution mass spectrometry (LC-HRMS). There was no variation of the metabolic profiles among plants that were collected from different populations. More than 160 compounds were found in the leaves, of which 72 were identified to the class level and 58 to the individual-compound level. The class of flavonoids proved to be the most widely represented (19 compounds), including six aglycones [quercetin, kaempferol, aromadendrin, 6-methoxytaxifolin, phloretin, and (+)-catechin] and mono- and diglycosides (the other 13 compounds). In the analyzed samples of , 14 fatty acid-related compounds were identified, but coumarins and furochromones that were found in were the most interesting result; furochromones khelloside, khellin, visnagin, and cimifugin were found in for the first time. Coumarins 5,7-dihydroxy-4-methylcoumarin, scoparone, fraxetin, and luvangetin and furochromones methoxsalen, 5- -methylvisammioside, and visamminol-3'-O-glucoside were detected for the first time in the genus Salisb. For all the above compounds, the structural formulas are given. Furthermore, detailed information (with structural formulas) is provided on the diversity of chromones and furochromones in other representatives of . The presence of chromones in plants of the genus confirms its closeness to the genus L. because chromones are synthesized by normal physiological processes only in these members of the Ranunculaceae family.