Preparation of Biodegradable Polycaprolactone/Poly (ethylene glycol)/Polycaprolactone (PCEC) Nanoparticles

• Published in: Drug delivery Vol. 15; no. 7; pp. 409 - 416
• Main Authors: Jia, Wen Juan, Gu, Ying Chun, Gou, Ma Ling, Dai, Mei, Li, Xing Yi, Kan, Bing, Yang, Jin Liang, Song, Qi Fang, Wei, Yu Quan, Qian, Zhi Yong
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.09.2008; Taylor & Francis
• Subjects: Animals; Cattle; Drug Delivery System; Drug Delivery Systems; Microscopy, Electron, Scanning; Nanoparticle; Nanoparticles; Polycaprolactone/Poly(Ethylene Glycol)/Polycaprolactone; Polyesters - administration & dosage; Polyesters - chemical synthesis; Polyesters - chemistry; Polyethylene Glycols - administration & dosage; Polyethylene Glycols - chemical synthesis; Polyethylene Glycols - chemistry; Protein Drug
• ISSN: 1071-7544; 1521-0464
• DOI: 10.1080/10717540802321727

Biodegradable polyetherester copolymer (PCL/PEG/PCL, PCEC) was synthesized by ring-opening polymerization of -caprolactone initiated by poly(ethylene glycol) (PEG). The PCEC nanoparticles were prepared by solvent diffusion method or w/o/w double emulsion method. The obtained particles' morphology was observed on scanning electron microscopy, and the particle size distribution was determined using Malvern laser particle sizer. Bovine serum albumin was used as the model water-soluble protein drug, which was successfully encapsulated in PCEC nanoparticles, the drug release behavior was studied in detail. The hydrolytic degradation behavior of the PCEC nanoparticles was also studied.