Respiratory and Systemic Toxicity of Inhaled Artificial Asian Sand Dust in Pigs

• Published in: Life (Basel, Switzerland) Vol. 11; no. 1; p. 25
• Main Authors: Kim, Keon, Kim, Seon-Deuk, Shin, Tae-Hoon, Bae, Chun-Sik, Ahn, Taeho, Shin, Sung-Shik, Kim, Ha-Jung, Lee, Chang-Min, Suh, Guk-Hyun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 04.01.2021; MDPI
• Subjects: Air pollution; Animals; Asian sand dust; Biocompatibility; Blood; Blood cells; Cytokines; domestic animal model; Domestic animals; Dust; Economic impact; Electrolytes; Enzymes; Epidemiology; Experimental research; Exposure; Gases; Health risks; Hogs; In vivo methods and tests; Inflammation; Laboratories; Laboratory animals; Laboratory tests; Outdoor air quality; Particulate emissions; Particulate matter; Pollutants; Pork; Public health; Respiratory system; respiratory toxicity; Sand; Swine; systemic inflammation; Toxicity; Tumor necrosis factor-TNF; China; Japan; systemic inflammation; Asian sand dust; respiratory toxicity; domestic animal model
• ISSN: 2075-1729; 2075-1729
• DOI: 10.3390/life11010025

Air pollution, particularly caused by Asian sand dust (ASD) and particulate matter (PM), has become one of the leading threats to public health. However, the majority of studies have primarily focused on epidemiological assessment, and in vivo toxicities of certain air pollutants have been poorly elucidated in medium/large-size laboratory animals. To investigate the impact of ASD in domestic animals, 16 Landrace pigs were exposed to an artificial ASD sandstorm for 6 h. All animals were divided in four cages, and a commercial yellow soil was used for generating artificial mineralogical particles. Blood samples were collected, and necropsies were performed before exposure and 6, 12, 24, and 72 h after exposure. Complete blood cell count and the levels of serum biochemical enzymes, blood gas, electrolytes, and a variety of inflammatory cytokines were evaluated. In addition, histopathological examination was conducted. Various test results proved acute lower airway disorders with systemic inflammation in pigs. To our knowledge, this study is the first to describe experimental research in domestic animals concerning the damage caused by artificial ASD exposure. The results of this study suggest that ASD has importance in terms of not only public health but also of ultimate economic losses in the pork industry.