Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice
Trichinellosis caused by Trichinella spiralis is a serious zoonosis with a worldwide distribution. Lentinan (LNT) is known to modulate the intestinal environment with noted health benefits, yet the effect of LNT against intestinal helminth is unknown. In our study, we first observed that LNT could t...
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Published in | Frontiers in immunology Vol. 13; p. 926765 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers
28.07.2022
Frontiers Media S.A |
Subjects | |
Online Access | Get full text |
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Summary: | Trichinellosis caused by
Trichinella spiralis
is a serious zoonosis with a worldwide distribution. Lentinan (LNT) is known to modulate the intestinal environment with noted health benefits, yet the effect of LNT against intestinal helminth is unknown. In our study, we first observed that LNT could trigger worm expulsion by promoting mucus layer functions through alteration of gut microbiota. LNT restored the abundance of
Bacteroidetes
and
Proteobacteria
altered by
T. spiralis
infection to the control group level. Interestingly, LNT triggered the production of butyrate. Then, we determined the deworming capacity of probiotics (butyrate-producing bacteria) in mice. Collectively, these findings indicated that LNT could modulate intestinal dysbiosis by
T. spiralis
, drive the expulsion of intestinal helminth and provided an easily implementable strategy to improve the host defence against
T. spiralis
infection. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 PMCID: PMC9371446 This article was submitted to Parasite Immunology, a section of the journal Frontiers in Immunology These authors have contributed equally to this work Reviewed by: Chiuan Yee Leow, Universiti Sains Malaysia (USM), Malaysia; Luis Fonte, Pedro Kouri National Institute of Tropical Medicine (IPK), Cuba Edited by: Lim Boon Huat, Universiti Sains Malaysia (USM), Malaysia |
ISSN: | 1664-3224 1664-3224 |
DOI: | 10.3389/fimmu.2022.926765 |