Lentinan -triggered butyrate-producing bacteria drive the expulsion of the intestinal helminth Trichinella spiralis in mice

Trichinellosis caused by Trichinella spiralis is a serious zoonosis with a worldwide distribution. Lentinan (LNT) is known to modulate the intestinal environment with noted health benefits, yet the effect of LNT against intestinal helminth is unknown. In our study, we first observed that LNT could t...

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Published inFrontiers in immunology Vol. 13; p. 926765
Main Authors Jin, Xuemin, Liu, Yi, Vallee, Isabelle, Karadjian, Gregory, Liu, Mingyuan, Liu, Xiaolei
Format Journal Article
LanguageEnglish
Published Frontiers 28.07.2022
Frontiers Media S.A
Subjects
butyrate
gut microbiota
Immunology
lentinan
Life Sciences
mucin
Trichinella spiralis
Gut microbiota
Trichinella spiralis
Mucin
Lentinan
Butyrate
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Summary:Trichinellosis caused by Trichinella spiralis is a serious zoonosis with a worldwide distribution. Lentinan (LNT) is known to modulate the intestinal environment with noted health benefits, yet the effect of LNT against intestinal helminth is unknown. In our study, we first observed that LNT could trigger worm expulsion by promoting mucus layer functions through alteration of gut microbiota. LNT restored the abundance of Bacteroidetes and Proteobacteria altered by T. spiralis infection to the control group level. Interestingly, LNT triggered the production of butyrate. Then, we determined the deworming capacity of probiotics (butyrate-producing bacteria) in mice. Collectively, these findings indicated that LNT could modulate intestinal dysbiosis by T. spiralis , drive the expulsion of intestinal helminth and provided an easily implementable strategy to improve the host defence against T. spiralis infection.
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PMCID: PMC9371446
This article was submitted to Parasite Immunology, a section of the journal Frontiers in Immunology
These authors have contributed equally to this work
Reviewed by: Chiuan Yee Leow, Universiti Sains Malaysia (USM), Malaysia; Luis Fonte, Pedro Kouri National Institute of Tropical Medicine (IPK), Cuba
Edited by: Lim Boon Huat, Universiti Sains Malaysia (USM), Malaysia
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.926765