Semi-Synthetic Polysaccharide Sulfates as Anticoagulant Coatings for PET, 1 - Cellulose Sulfate

• Published in: Macromolecular bioscience Vol. 11; no. 4; pp. 549 - 556
• Main Authors: Gericke, Martin, Doliška, Aleš, Stana, Jan, Liebert, Tim, Heinze, Thomas, Stana-Kleinschek, Karin
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 08.04.2011; WILEY‐VCH Verlag; Wiley-VCH
• Subjects: Adult; anticoagulant coatings; Anticoagulants - chemistry; Applied sciences; blood compatibility; Cellulose - analogs & derivatives; Cellulose - chemistry; Cellulose and derivatives; cellulose sulfates; chitosan; Coated Materials, Biocompatible - chemistry; Exact sciences and technology; Humans; layer-by-layer assemblies; Male; Materials Testing; Natural polymers; Physicochemistry of polymers; Polyethylene Glycols - chemistry; Polyethylene Terephthalates; Biological properties; Self-assembled layer; Ethylene terephthalate polymer; Self assembly; Clotting time; Cellulose sulfate; Cellulose; Multiple layer; Cellulose inorganic ester; Anticoagulant; Surface topography; Experimental study; Coated material; Blood; Sulfatation; Homogeneous reaction; Chemical modification; Preparation; Oside polymer; Chitosan; Growth from solution
• ISSN: 1616-5187; 1616-5195
• DOI: 10.1002/mabi.201000419

In the present study, blood‐compatible PET surfaces were prepared by coating with anticoagulant cellulose sulfates that were synthesized homogeneously in ionic liquids. The adsorption behavior of polysaccharides on PET films was investigated using QCM‐D. It was demonstrated that pre‐coating with different amino‐group‐containing polysaccharides improves the affinity toward cellulose sulfate. Moreover, the effect of different degrees of sulfation on the adsorption process was evaluated. Based on these results, several layer‐by‐layer coated PET foils were prepared that showed significantly improved blood compatibility compared to the initial untreated material. Anticoagulant cellulose sulfates, which are easily accessible by homogeneous synthesis in ionic liquids, can be used to improve the blood compatibility of PET‐based materials. QCM‐D studies revealed that coating with different amino‐group‐containing polysaccharides can improve the subsequent adsorption of an anticoagulant layer.