Recent Advances in Nanozyme Research

• Published in: Advanced materials (Weinheim) Vol. 31; no. 45; pp. e1805368 - n/a
• Main Authors: Wang, Hui, Wan, Kaiwei, Shi, Xinghua
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.11.2019
• Subjects: Biomimetic Materials - chemistry; Catalysis; Catalytic activity; Chemical synthesis; Environmental protection; enzyme mimic; Enzymes; Enzymes - metabolism; Materials science; Medical imaging; Nanomaterials; Nanostructures - chemistry; Nanotechnology; Nanotechnology - methods; nanozymes; reactive oxygen species (ROS); theory and mechanisms; nanozymes; catalysis; theory and mechanisms; reactive oxygen species (ROS); enzyme mimic
• ISSN: 0935-9648; 1521-4095
• DOI: 10.1002/adma.201805368

As a new generation of artificial enzymes, nanozymes have the advantages of high catalytic activity, good stability, low cost, and other unique properties of nanomaterials. Due to their wide range of potential applications, they have become an emerging field bridging nanotechnology and biology, attracting researchers in various fields to design and synthesize highly catalytically active nanozymes. However, the thorough understanding of experimental phenomena and the mechanisms beneath practical applications of nanozymes limits their rapid development. Herein, the progress of experimental and computational research of nanozymes on two issues over the past decade is briefly reviewed: (1) experimental development of new nanozymes mimicking different types of enzymes. This covers their structures and applications ranging from biosensing and bioimaging to therapeutics and environmental protection. (2) The catalytic mechanism proposed by experimental and theoretical study. The challenges and future directions of computational research in this field are also discussed. The experimental development of new nanozymes mimicking different types of enzymes, their applications in biosensing, bioimaging, therapeutics, and environmental protection, and the catalytic mechanisms proposed by theoretical study are reviewed.