Intracellular Hydrogelation of Small Molecules Inhibits Bacterial Growth

Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme‐regulated self‐assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, un...

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Published inAngewandte Chemie International Edition Vol. 46; no. 43; pp. 8216 - 8219
Main Authors Yang, Zhimou, Liang, Gaolin, Guo, Zufeng, Guo, Zhihong, Xu, Bing
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 05.11.2007
WILEY‐VCH Verlag
Wiley
Subjects
Bacteria - growth & development
Chemistry
Chemistry, Multidisciplinary
Chromatography, High Pressure Liquid
Electrophoresis, Polyacrylamide Gel
enzymes
hydrogelation
Hydrogels - chemistry
hydrolysis
inhibitors
Microscopy, Electron, Transmission
Physical Sciences
Science & Technology
self-assembly
NANOFIBERS
SUPRAMOLECULAR HYDROGELS
ENZYMATIC FORMATION
EXPRESSION
ESCHERICHIA-COLI
IN-VIVO
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Summary:Control from within: Supramolecular hydrogelation to form nanostructures intracellularly (see picture) has been developed as a new methodology to control the fate of cells. Enzyme‐regulated self‐assembly of small molecules inside cells could lead to a new paradigm for managing cellular processes, understanding cellular functions, and developing new therapeutics through supramolecular chemistry.
Bibliography:Research Grants Council of Hong Kong - No. HKU2/05C; No. 604905; No. 600504
ark:/67375/WNG-LJSJKQFQ-B
ArticleID:ANIE200701697
This work was partially supported by the Research Grants Council of Hong Kong (HKU2/05C, 604905, 600504), and HKUST (EHIA). B.X. thanks Dr. P. L. Ho for his suggestions in revising the manuscript.
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ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
1521-3773
DOI:10.1002/anie.200701697