Multiple functions of S100A10, an important cancer promoter

The S100 group of calcium binding proteins is composed of 21 members that exhibit tissue/cell specific expressions. These S100 proteins bind a diverse range of targets and regulate multiple cellular processes, including proliferation, migration and differentiation. S100A10, also known as p11, binds...

Full description

Saved in:
Bibliographic Details
Published inPathology international Vol. 69; no. 11; pp. 629 - 636
Main Authors Saiki, Yuriko, Horii, Akira
Format Journal Article
LanguageEnglish
Published Australia Wiley Subscription Services, Inc 01.11.2019
Subjects
annexin A2
ANXA2
Breast
Breast cancer
Calcium
Calcium-binding protein
Cancer
cancer invasion
Chemoresistance
Gallbladder
Leukemia
Lung cancer
Menopause
metastasis
p11
Pancreas
Plasmin
plasminogen receptor
Proteins
S100 protein
S100A10
p11
ANXA2
cancer invasion
metastasis
annexin A2
plasminogen receptor
S100A10
Online AccessGet full text

Cover

More Information
Summary:The S100 group of calcium binding proteins is composed of 21 members that exhibit tissue/cell specific expressions. These S100 proteins bind a diverse range of targets and regulate multiple cellular processes, including proliferation, migration and differentiation. S100A10, also known as p11, binds mainly to annexin A2 and mediates the conversion of plasminogen to an active protease, plasmin. Higher S100A10 expression has been reported to link to worse outcome and/or chemoresistance in a number of cancer types in lung, breast, ovary, pancreas, gall bladder and colorectum and leukemia although some discrepancy was reported. In this review, we focused on the roles of the S100A10 in cancer. We summarized its biological functions, role in cancer progression, prognostic value and targeting of S100A10 for cancer therapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ISSN:1320-5463
1440-1827
1440-1827
DOI:10.1111/pin.12861