The pharmacological basis of coronary and systemic vasodilator actions of diazepam (Valium)
Summary 1 The effects of α and β‐adrenoceptor blockade, depletion of catecholamine stores, vagotomy, atropine, and ganglionic blockade on diazepam‐induced vasodilatation were investigated in forty‐six anaesthetized dogs. 2 Coronary blood flow was measured by timed collections of coronary venous effl...
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Published in | British journal of pharmacology Vol. 39; no. 2; pp. 261 - 274 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.06.1970
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Subjects | |
Online Access | Get full text |
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Summary: | Summary
1
The effects of α and β‐adrenoceptor blockade, depletion of catecholamine stores, vagotomy, atropine, and ganglionic blockade on diazepam‐induced vasodilatation were investigated in forty‐six anaesthetized dogs.
2
Coronary blood flow was measured by timed collections of coronary venous efflux from fibrillating, decompressed ventricles; coronary and systemic vascular resistances were determined during total cardiopulmonary bypass under conditions of normothermia and constant aortic (coronary artery) pressure.
3
No significant alteration in the vasodilatation produced by diazepam was observed following either vagotomy or α‐adrenoceptor blockade; partial inhibition of vasodilatation occurred after β‐adrenoceptor blockade or catecholamine depletion, and nearly total inhibition was observed after small doses of atropine or ganglion‐blocking agents.
4
The results suggest that diazepam may act as a specific ganglion‐stimulant, causing active sympathetic and cholinergic vasodilatation. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-1188 1476-5381 |
DOI: | 10.1111/j.1476-5381.1970.tb12890.x |