Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked-X Four-Way Junction by a Small Molecule

• Published in: Angewandte Chemie International Edition Vol. 46; no. 21; pp. 3850 - 3854
• Main Authors: Brogden, Anna L., Hopcroft, Nicholas H., Searcey, Mark, Cardin, Christine J.
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.01.2007; WILEY‐VCH Verlag; Wiley
• Subjects: Adenine - chemistry; Binding Sites; bridging ligands; Chemistry; Chemistry, Multidisciplinary; DNA structures; DNA, Cruciform - chemistry; ligand design; Ligands; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Physical Sciences; Science & Technology; structure elucidation; X‒ray diffraction; bridging ligands; CELLS; RECOMBINATION; DNA structures; CRYSTAL-STRUCTURE; SEQUENCE; POISON; ligand design; X-ray diffraction; structure elucidation; G-QUADRUPLEX; BINDING

Planning a Holliday: A new mode of binding to a stacked‐X, four‐way Holliday junction is described in which a chromophore molecule binds across the center of the junction and two adenine residues are replaced by the acridine chromophores at either side of the crossover. This binding mode is specific...