Ligand Bridging of the DNA Holliday Junction: Molecular Recognition of a Stacked-X Four-Way Junction by a Small Molecule

Planning a Holliday: A new mode of binding to a stacked‐X, four‐way Holliday junction is described in which a chromophore molecule binds across the center of the junction and two adenine residues are replaced by the acridine chromophores at either side of the crossover. This binding mode is specific...

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Bibliographic Details
Published inAngewandte Chemie International Edition Vol. 46; no. 21; pp. 3850 - 3854
Main Authors Brogden, Anna L., Hopcroft, Nicholas H., Searcey, Mark, Cardin, Christine J.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.01.2007
WILEY‐VCH Verlag
Wiley
Subjects
Adenine - chemistry
Binding Sites
bridging ligands
Chemistry
Chemistry, Multidisciplinary
DNA structures
DNA, Cruciform - chemistry
ligand design
Ligands
Models, Molecular
Molecular Structure
Nucleic Acid Conformation
Physical Sciences
Science & Technology
structure elucidation
X‒ray diffraction
bridging ligands
CELLS
RECOMBINATION
DNA structures
CRYSTAL-STRUCTURE
SEQUENCE
POISON
ligand design
X-ray diffraction
structure elucidation
G-QUADRUPLEX
BINDING
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Summary:Planning a Holliday: A new mode of binding to a stacked‐X, four‐way Holliday junction is described in which a chromophore molecule binds across the center of the junction and two adenine residues are replaced by the acridine chromophores at either side of the crossover. This binding mode is specific for the Holliday junction and does not cause unwinding of the DNA helices.
Bibliography:ark:/67375/WNG-RJQ0XXT3-4
istex:2720A3BA926785528FCF8FFCF016FED14A049C71
BBSRC
University of Reading
the School of Pharmacy, University of London
European Community - No. RII3/CT/2004/5060008
ArticleID:ANIE200603760
We are grateful to the University of Reading, the School of Pharmacy, University of London (to A.L.B.), and the BBSRC (to N.H.H.) for financial support. Our use of the beamline X11 at EMBl/DESY, Hamburg, was funded by the European Community-Research Infrastructure Action under the FP6, structuring the European Research Area Program contract number RII3/CT/2004/5060008, and we thank Santosh Panjikar for his help during data collection (NDB code: DD0083, PDB code: 2GWA).
We are grateful to the University of Reading, the School of Pharmacy, University of London (to A.L.B.), and the BBSRC (to N.H.H.) for financial support. Our use of the beamline X11 at EMBl/DESY, Hamburg, was funded by the European Community—Research Infrastructure Action under the FP6, structuring the European Research Area Program contract number RII3/CT/2004/5060008, and we thank Santosh Panjikar for his help during data collection (NDB code: DD0083, PDB code: 2GWA).
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researchfish
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200603760