Bioactive hydroxyphenylpyrrole-dicarboxylic acids from a new marine Halomonas sp.: production and structure elucidation
The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and 3,4-bis(4'-hydroxy- phenyl)pyrrole-2,5-dicarboxylic acid (HPPD-2). In initial cultivations using marine broth, only low contents of these...
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Published in | Applied microbiology and biotechnology Vol. 72; no. 4; pp. 816 - 822 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Berlin
Berlin/Heidelberg : Springer-Verlag
01.10.2006
Springer Springer Nature B.V |
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Abstract | The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and 3,4-bis(4'-hydroxy- phenyl)pyrrole-2,5-dicarboxylic acid (HPPD-2). In initial cultivations using marine broth, only low contents of these compounds have been isolated. Improving the conditions and growing the strain on artificial seawater supplemented with tryptone 10 g l-¹, yeast extract 5 g l-¹, l-tyrosine 0.6 g l-¹, glycine 1 g l-¹, and glucose 6 g l⁻¹, the growth-associated HPPD-1 and HPPD-2 production of a 40-l batch cultivation reached the amounts of 47 mg l-¹ and 116 mg l-¹, respectively, after 65 h. Both compounds showed potent anti-tumor-promoting activities. |
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AbstractList | The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and 3,4-bis(4'-hydroxy- phenyl)pyrrole-2,5-dicarboxylic acid (HPPD-2). In initial cultivations using marine broth, only low contents of these compounds have been isolated. Improving the conditions and growing the strain on artificial seawater supplemented with tryptone 10 g l super(-1), yeast extract 5 g l super(-1), l-tyrosine 0.6 g l super(-1), glycine 1 g l super(-1), and glucose 6 g l super(-1), the growth-associated HPPD-1 and HPPD-2 production of a 40-l batch cultivation reached the amounts of 47 mg l super(-1) and 116 mg l super(-1), respectively, after 65 h. Both compounds showed potent anti-tumor-promoting activities. The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and 3,4-bis(4'-hydroxy- phenyl)pyrrole-2,5-dicarboxylic acid (HPPD-2). In initial cultivations using marine broth, only low contents of these compounds have been isolated. Improving the conditions and growing the strain on artificial seawater supplemented with tryptone 10 g l(-1), yeast extract 5 g l(-1), L-tyrosine 0.6 g l(-1), glycine 1 g l(-1), and glucose 6 g l(-1), the growth-associated HPPD-1 and HPPD-2 production of a 40-l batch cultivation reached the amounts of 47 mg l(-1) and 116 mg l(-1), respectively, after 65 h. Both compounds showed potent anti-tumor-promoting activities. The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and 3,4-bis(4'-hydroxy- phenyl)pyrrole-2,5-dicarboxylic acid (HPPD-2). In initial cultivations using marine broth, only low contents of these compounds have been isolated. Improving the conditions and growing the strain on artificial seawater supplemented with tryptone 10 g l^sup -1^, yeast extract 5 g l^sup -1^, l-tyrosine 0.6 g l^sup -1^, glycine 1 g l^sup -1^, and glucose 6 g l^sup -1^, the growth-associated HPPD-1 and HPPD-2 production of a 40-l batch cultivation reached the amounts of 47 mg l^sup -1^ and 116 mg l^sup -1^, respectively, after 65 h. Both compounds showed potent anti-tumor-promoting activities.[PUBLICATION ABSTRACT] The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and 3,4-bis(4'-hydroxy- phenyl)pyrrole-2,5-dicarboxylic acid (HPPD-2). In initial cultivations using marine broth, only low contents of these compounds have been isolated. Improving the conditions and growing the strain on artificial seawater supplemented with tryptone 10 g l-¹, yeast extract 5 g l-¹, l-tyrosine 0.6 g l-¹, glycine 1 g l-¹, and glucose 6 g l⁻¹, the growth-associated HPPD-1 and HPPD-2 production of a 40-l batch cultivation reached the amounts of 47 mg l-¹ and 116 mg l-¹, respectively, after 65 h. Both compounds showed potent anti-tumor-promoting activities. |
Author | Liang, L Wang, L Brinkhoff, T Tokuda, H Zeeck, A Stevens, H Bitzer, J Bach, G Groβe, T Lang, S Simon, M |
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Keywords | Marine environment Bacteria Dicarboxylic acid Halomonas Halomonadaceae Production |
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Snippet | The new marine Halomonas sp. strain GWS-BW-H8hM (DSM 17996) was found to produce 3-(4'-hydroxyphenyl)-4-phenylpyrrole-2,5-dicarboxylic acid (HPPD-1) and... |
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SubjectTerms | Acids Anticarcinogenic Agents - pharmacology Antineoplastic Agents - pharmacology Artificial seawater Biochemistry Biological and medical sciences Biotechnology Dicarboxylic Acids - chemistry Dicarboxylic Acids - isolation & purification Dicarboxylic Acids - pharmacology Fundamental and applied biological sciences. Psychology Halomonas Halomonas - chemistry Halomonas - metabolism Marine Marine ecology Seawater Studies Yeasts |
Title | Bioactive hydroxyphenylpyrrole-dicarboxylic acids from a new marine Halomonas sp.: production and structure elucidation |
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