Supernumerary minute ring chromosome 14 in a man with primary infertility and left varicocele
Objective To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. Design Case report. Setting Urologic infertility clinic in a university hospital. Patient(s) Male patient presenting with primary infertility. Interventi...
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Published in | Fertility and sterility Vol. 87; no. 5; pp. 1213.e1 - 1213.e3 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.05.2007
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Abstract | Objective To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. Design Case report. Setting Urologic infertility clinic in a university hospital. Patient(s) Male patient presenting with primary infertility. Intervention(s) Karyotyping, genetic counseling, and microsurgical left varicocelectomy. Main Outcome Measure(s) Sperm concentration and motility, chromosomal number and structure. Result(s) Fluorescence in situ hybridization revealing SMRC 14. Sperm concentration and motility improved after left varicocele repair. Conclusion(s) A karyotype should be included in the evaluation of severe oligospermia. Although SMRC 14 may be associated with fertility problems, repair of a coexisting varicocele should be considered in these patients. |
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AbstractList | OBJECTIVETo describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele.DESIGNCase report.SETTINGUrologic infertility clinic in a university hospital.PATIENT(S)Male patient presenting with primary infertility.INTERVENTION(S)Karyotyping, genetic counseling, and microsurgical left varicocelectomy.MAIN OUTCOME MEASURE(S)Sperm concentration and motility, chromosomal number and structure.RESULT(S)Fluorescence in situ hybridization revealing SMRC 14. Sperm concentration and motility improved after left varicocele repair.CONCLUSION(S)A karyotype should be included in the evaluation of severe oligospermia. Although SMRC 14 may be associated with fertility problems, repair of a coexisting varicocele should be considered in these patients. Objective To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. Design Case report. Setting Urologic infertility clinic in a university hospital. Patient(s) Male patient presenting with primary infertility. Intervention(s) Karyotyping, genetic counseling, and microsurgical left varicocelectomy. Main Outcome Measure(s) Sperm concentration and motility, chromosomal number and structure. Result(s) Fluorescence in situ hybridization revealing SMRC 14. Sperm concentration and motility improved after left varicocele repair. Conclusion(s) A karyotype should be included in the evaluation of severe oligospermia. Although SMRC 14 may be associated with fertility problems, repair of a coexisting varicocele should be considered in these patients. To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. Case report. Urologic infertility clinic in a university hospital. Male patient presenting with primary infertility. Karyotyping, genetic counseling, and microsurgical left varicocelectomy. Sperm concentration and motility, chromosomal number and structure. Fluorescence in situ hybridization revealing SMRC 14. Sperm concentration and motility improved after left varicocele repair. A karyotype should be included in the evaluation of severe oligospermia. Although SMRC 14 may be associated with fertility problems, repair of a coexisting varicocele should be considered in these patients. |
Author | Patil, Shivanand R., Ph.D Sparks, Amy E.T., Ph.D Wald, Moshe, M.D Syrop, Craig H., M.D Stahl, Brandon C., M.D |
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Cites_doi | 10.1002/pd.1970120203 10.1159/000079572 10.1111/j.1399-0004.1993.tb03849.x 10.1002/ajmg.1320560124 10.1007/s00439-003-1016-3 10.1002/(SICI)1096-8628(19980203)75:4<355::AID-AJMG4>3.0.CO;2-P 10.1002/(SICI)1097-0223(199905)19:5<480::AID-PD547>3.0.CO;2-H 10.1093/humrep/11.suppl_4.1 10.1159/000086909 10.1002/(SICI)1096-8628(19980203)75:4<367::AID-AJMG5>3.0.CO;2-N 10.1530/rep.0.1210655 10.1002/ajmg.a.10100 |
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Snippet | Objective To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. Design Case... To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. Case report. Urologic... OBJECTIVETo describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele.DESIGNCase... |
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SubjectTerms | Adult Chromosomes, Human, Pair 14 Humans Infertility Infertility, Male - diagnosis Infertility, Male - genetics Infertility, Male - surgery Internal Medicine karyotyping Male Obstetrics and Gynecology oligospermia Ring Chromosomes sex chromosome disorders varicocele Varicocele - diagnosis Varicocele - genetics Varicocele - surgery |
Title | Supernumerary minute ring chromosome 14 in a man with primary infertility and left varicocele |
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