Supernumerary minute ring chromosome 14 in a man with primary infertility and left varicocele

Objective To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. Design Case report. Setting Urologic infertility clinic in a university hospital. Patient(s) Male patient presenting with primary infertility. Interventi...

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Published inFertility and sterility Vol. 87; no. 5; pp. 1213.e1 - 1213.e3
Main Authors Stahl, Brandon C., M.D, Patil, Shivanand R., Ph.D, Syrop, Craig H., M.D, Sparks, Amy E.T., Ph.D, Wald, Moshe, M.D
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2007
Subjects
Adult
Chromosomes, Human, Pair 14
Humans
Infertility
Infertility, Male - diagnosis
Infertility, Male - genetics
Infertility, Male - surgery
Internal Medicine
karyotyping
Male
Obstetrics and Gynecology
oligospermia
Ring Chromosomes
sex chromosome disorders
varicocele
Varicocele - diagnosis
Varicocele - genetics
Varicocele - surgery
sex chromosome disorders
oligospermia
karyotyping
Infertility
male
varicocele
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Summary:Objective To describe a case of supernumerary minute ring chromosome (SMRC) in an infertile man, with the concurrent finding of a left varicocele. Design Case report. Setting Urologic infertility clinic in a university hospital. Patient(s) Male patient presenting with primary infertility. Intervention(s) Karyotyping, genetic counseling, and microsurgical left varicocelectomy. Main Outcome Measure(s) Sperm concentration and motility, chromosomal number and structure. Result(s) Fluorescence in situ hybridization revealing SMRC 14. Sperm concentration and motility improved after left varicocele repair. Conclusion(s) A karyotype should be included in the evaluation of severe oligospermia. Although SMRC 14 may be associated with fertility problems, repair of a coexisting varicocele should be considered in these patients.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0015-0282
1556-5653
DOI:10.1016/j.fertnstert.2006.09.008