Fatty acid synthesis and elongation in yeast

Fatty acids are essential compounds in the cell. Since the yeast Saccharomyces cerevisiae does not feed typically on fatty acids, cellular function and growth relies on endogenous synthesis. Since all cellular organelles are involved in – or dependent on – fatty acid synthesis, multiple levels of co...

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Bibliographic Details
Published inBiochimica et biophysica acta Vol. 1771; no. 3; pp. 255 - 270
Main Authors Tehlivets, Oksana, Scheuringer, Kim, Kohlwein, Sepp D.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2007
Subjects
Acetyl-CoA Carboxylase - metabolism
Coenzymes - metabolism
Cytosol - metabolism
Endoplasmic Reticulum - metabolism
Fatty acid
Fatty acid elongation
Fatty Acid Synthases - metabolism
Fatty Acids - biosynthesis
Lipid metabolism
Mitochondria - enzymology
Mitochondria - metabolism
Regulation
Saccharomyces cerevisiae
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - metabolism
Yeast
Regulation
Yeast
Lipid metabolism
Saccharomyces cerevisiae
Fatty acid
Fatty acid elongation
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Summary:Fatty acids are essential compounds in the cell. Since the yeast Saccharomyces cerevisiae does not feed typically on fatty acids, cellular function and growth relies on endogenous synthesis. Since all cellular organelles are involved in – or dependent on – fatty acid synthesis, multiple levels of control may exist to ensure proper fatty acid composition and homeostasis. In this review, we summarize what is currently known about enzymes involved in cellular fatty acid synthesis and elongation, and discuss potential links between fatty acid metabolism, physiology and cellular regulation.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1388-1981
0006-3002
1879-2618
DOI:10.1016/j.bbalip.2006.07.004