Anticancer activity of new depsipeptide compound isolated from an endophytic fungus
A novel depsipeptide (PM181110) was purified from an endophytic fungus Phomopsis glabrae isolated from the leaves of Pongamia pinnata (family Fabaceae). The chemical structure of PM181110 was elucidated using physiochemical properties, 2D NMR and other spectroscopic methods. PM181110 is very close i...
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Published in | Journal of antibiotics Vol. 67; no. 10; pp. 697 - 701 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
London
Nature Publishing Group UK
01.10.2014
Springer Nature Nature Publishing Group |
Subjects | |
Online Access | Get full text |
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Summary: | A novel depsipeptide (PM181110) was purified from an endophytic fungus
Phomopsis glabrae
isolated from the leaves of
Pongamia pinnata
(family Fabaceae). The chemical structure of PM181110 was elucidated using physiochemical properties, 2D NMR and other spectroscopic methods. PM181110 is very close in structure to FE399. The compound exhibited
in vitro
anticancer activity against 40 human cancer cell lines with a mean IC
50
value of 0.089 μ
M
and
ex vivo
efficacy towards 24 human tumor xenografts (mean IC
50
=0.245 μ
M
). |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0021-8820 1881-1469 |
DOI: | 10.1038/ja.2014.58 |