Anticancer activity of new depsipeptide compound isolated from an endophytic fungus

• Published in: Journal of antibiotics Vol. 67; no. 10; pp. 697 - 701
• Main Authors: Verekar, Shilpa Amit, Mishra, Prabhu Dutt, Sreekumar, Eyyammadichiyil Sankaranarayanan, Deshmukh, Sunil Kumar, Fiebig, Heinz-Herbert, Kelter, Gerhard, Maier, Armin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2014; Springer Nature; Nature Publishing Group
• Subjects: 631/154/349; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; Ascomycota - chemistry; Ascomycota - isolation & purification; Bacteriology; Biological Products - chemistry; Biological Products - isolation & purification; Biological Products - pharmacology; Biomedical and Life Sciences; Bioorganic Chemistry; Biotechnology & Applied Microbiology; Cell Line, Tumor; Chemical Phenomena; Depsipeptides - chemistry; Depsipeptides - isolation & purification; Depsipeptides - pharmacology; Endophytes - chemistry; Endophytes - isolation & purification; Humans; Immunology; Inhibitory Concentration 50; Life Sciences; Life Sciences & Biomedicine; Medicinal Chemistry; Microbiology; Millettia - microbiology; Molecular Structure; Organic Chemistry; original-article; Pharmacology & Pharmacy; Plant Leaves - microbiology; Science & Technology; Spectrum Analysis; ASSAY
• ISSN: 0021-8820; 1881-1469
• DOI: 10.1038/ja.2014.58

A novel depsipeptide (PM181110) was purified from an endophytic fungus Phomopsis glabrae isolated from the leaves of Pongamia pinnata (family Fabaceae). The chemical structure of PM181110 was elucidated using physiochemical properties, 2D NMR and other spectroscopic methods. PM181110 is very close in structure to FE399. The compound exhibited in vitro anticancer activity against 40 human cancer cell lines with a mean IC 50 value of 0.089 μ M and ex vivo efficacy towards 24 human tumor xenografts (mean IC 50 =0.245 μ M ).