Naproxen-induced pseudolymphoma syndrome: a case report

Abstract Drug-induced pseudolymphoma syndrome is a rare form of adverse cutaneous drug reaction. Its clinical and histological presentation may mimic mycosis fungoides, which sometimes leads to misdiagnosis and unnecessary treatments. We describe the case of a 65-year-old man with a generalized prur...

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Bibliographic Details
Published inZhonghua pi fu ke yi xue za zhi Vol. 28; no. 1; pp. 27 - 31
Main Authors Lin, Shang-Hong, Wang, Cheng-Yu, Ho, Ji-Chen, Wu, Wei-Ming
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2010
Wolters Kluwer Medknow Publications
Subjects
Dermatology
Maculopapular eruption
Naproxen
Pseudolymphoma syndrome
Pseudolymphoma syndrome
Naproxen
Maculopapular eruption
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Summary:Abstract Drug-induced pseudolymphoma syndrome is a rare form of adverse cutaneous drug reaction. Its clinical and histological presentation may mimic mycosis fungoides, which sometimes leads to misdiagnosis and unnecessary treatments. We describe the case of a 65-year-old man with a generalized pruritic and confluent maculopapular eruption. His history of skin lesions was concordant with medication and resolved after discontinuation. However, microscopic examination showed characteristic features of mycosis fungoides, including Pautrier-like microabscesses and cerebriform nuclei of atypical lymphocytes. The immunohistochemical study showed CD4/CD8 infiltrate ratio to be 1 in the epidermis. The histopathological result of a second skin biopsy was compatible with drug eruption. This experience demonstrates that combining clinical history, histological and immunohistochemical findings is crucial for a definite diagnosis of PLS.
ISSN:1027-8117
DOI:10.1016/S1027-8117(10)60004-3