Does a positive pretransplant crossmatch affect long-term outcome in liver transplantation?

Despite the historical success of liver transplantation in the face of a positive lymphocytic crossmatch, increased incidence of acute cellular rejection and graft loss have been reported in this setting. Given the potential adverse effects of antirejection treatment, especially in hepatitis C virus...

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Bibliographic Details
Published inTransplantation Vol. 91; no. 3; p. 261
Main Authors Al-Sibae, Mohamad R, Koffron, Alan J, Raofi, Vandad
Format Journal Article
LanguageEnglish
Published United States 15.02.2011
Subjects
Graft Rejection - immunology
Graft Rejection - prevention & control
Hepatitis C - surgery
Histocompatibility Testing
Humans
Liver Transplantation - immunology
Treatment Outcome
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Summary:Despite the historical success of liver transplantation in the face of a positive lymphocytic crossmatch, increased incidence of acute cellular rejection and graft loss have been reported in this setting. Given the potential adverse effects of antirejection treatment, especially in hepatitis C virus-positive recipients, identification of predisposing factors could allow for better surveillance, avoidance of rejection, and potentially better graft outcomes.
ISSN:1534-6080
DOI:10.1097/tp.0b013e318204758c