Clustered protocadherins

The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic locus, and this remarkable genomic organization is highly conserved from teleosts to humans. These clustered Pcdhs are differentially expressed in individual neurons, they engage in homophilic trans-interactions...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 140; no. 16; pp. 3297 - 3302
Main Authors Chen, Weisheng V., Maniatis, Tom
Format Journal Article
LanguageEnglish
Published England Company of Biologists 15.08.2013
Subjects
Animals
Binding Sites
Cadherins - genetics
Cadherins - metabolism
CCCTC-Binding Factor
Development at A Glance
Exons
Humans
Mice
Multigene Family
Neural Pathways - metabolism
Promoter Regions, Genetic
Protein Interaction Mapping
Protein Isoforms - genetics
Protein Isoforms - metabolism
Purkinje Cells - cytology
Purkinje Cells - metabolism
Repressor Proteins - genetics
Repressor Proteins - metabolism
Synapses - metabolism
Teleostei
Transcription, Genetic
Single cell diversity
CTCF
Cohesin
Homophilic interaction
Promoter choice
Self-avoidance
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Summary:The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic locus, and this remarkable genomic organization is highly conserved from teleosts to humans. These clustered Pcdhs are differentially expressed in individual neurons, they engage in homophilic trans-interactions as multimers and they are required for diverse neurodevelopmental processes, including neurite self-avoidance. Here, we provide a concise overview of the molecular and cellular biology of clustered Pcdhs, highlighting how they generate single cell diversity in the vertebrate nervous system and how such diversity may be used in neural circuit assembly.
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ISSN:0950-1991
1477-9129
1477-9129
DOI:10.1242/dev.090621