Oxidative stress and mitochondrial dysfunction in glaucoma

Graphical abstract Highlights ► Oxidative stress is thought to contribute to the pathogenesis of glaucoma. ► Mitochondria are a central source and target of oxidative stress. ► Signs of oxidative stress and damage are present in glaucomatous tissue. ► Reactive oxygen species can cause retinal gangli...

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Bibliographic Details
Published inCurrent opinion in pharmacology Vol. 13; no. 1; pp. 12 - 15
Main Authors Chrysostomou, Vicki, Rezania, Fatemeh, Trounce, Ian A, Crowston, Jonathan G
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2013
Subjects
Animals
Antioxidants - therapeutic use
Glaucoma - drug therapy
Glaucoma - metabolism
Humans
Internal Medicine
Medical Education
Mitochondria - metabolism
Neuroprotective Agents - therapeutic use
Oxidative Stress
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Summary:Graphical abstract Highlights ► Oxidative stress is thought to contribute to the pathogenesis of glaucoma. ► Mitochondria are a central source and target of oxidative stress. ► Signs of oxidative stress and damage are present in glaucomatous tissue. ► Reactive oxygen species can cause retinal ganglion cell death directly or indirectly. ► Mitochondrial antioxidants may improve disease outcomes in glaucoma.
ISSN:1471-4892
1471-4973
DOI:10.1016/j.coph.2012.09.008