Role of substance P in the cardiovascular system

Abstract This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions of substance P are...

Full description

Saved in:
Bibliographic Details
Published inNeuropeptides (Edinburgh) Vol. 58; pp. 41 - 51
Main Authors Mistrova, Eliska, Kruzliak, Peter, Chottova Dvorakova, Magdalena
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier Ltd 01.08.2016
Subjects
Advanced Basic Science
Animals
Antagonist
Brain - physiology
Brain Ischemia - physiopathology
Cardiovascular Physiological Phenomena
Cardiovascular regulation
Endocrinology & Metabolism
Heart Diseases - physiopathology
Humans
Myocardial Ischemia - physiopathology
Neurokinin-1 Receptor Antagonists - pharmacology
NK1 receptor
Receptors, Neurokinin-1 - physiology
Signal Transduction
Substance P
Substance P - biosynthesis
Substance P - metabolism
Substance P - physiology
Antagonist
NK1 receptor
Cardiovascular regulation
Substance P
Online AccessGet full text

Cover

More Information
Summary:Abstract This article provides an overview of the structure and function of substance P signalling system and its involvement in the cardiovascular regulation. Substance P is an undecapeptide originating from TAC1 gen and belonging to the tachykinin family. The biological actions of substance P are mainly mediated through neurokinin receptor 1 since substance P is the ligand with the highest affinity to neurokinin receptor 1. Substance P is widely distributed within the central and peripheral nervous systems as well as in the cardiovascular system. Substance P is involved in the regulation of heart frequency, blood pressure and in the stretching of vessels. Substance P plays an important role in ischemia and reperfusion and cardiovascular response to stress. Additionally, it has been also implicated in angiogenesis, pain transmission and inflammation. The substance P/neurokinin receptor 1 receptor system is involved in the molecular bases of many human pathological processes. Antagonists of neurokinin receptor 1 receptor could provide clinical solutions for a variety of diseases. Neurokinin receptor 1 antagonists are already used in the prevention of chemotherapy induced nausea and vomiting.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2015.12.005