Inorganic sulfur-nitrogen compounds: from gunpowder chemistry to the forefront of biological signaling
The reactions between inorganic sulfur and nitrogen-bearing compounds to form S-N containing species have a long history and, besides assuming importance in industrial synthetic processes, are of relevance to microbial metabolism; waste water treatment; aquatic, soil and atmospheric chemistry; and c...
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| Published in | Dalton transactions : an international journal of inorganic chemistry Vol. 45; no. 14; pp. 598 - 5919 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
14.04.2016
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| Subjects | |
| Online Access | Get full text |
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| Summary: | The reactions between inorganic sulfur and nitrogen-bearing compounds to form S-N containing species have a long history and, besides assuming importance in industrial synthetic processes, are of relevance to microbial metabolism; waste water treatment; aquatic, soil and atmospheric chemistry; and combustion processes. The recent discovery that hydrogen sulfide and nitric oxide exert often similar, sometimes mutually dependent effects in a variety of biological systems, and that the chemical interaction of these two species leads to formation of S-N compounds brought this chemistry to the attention of physiologists, biochemists and physicians. We here provide a perspective about the potential role of S-N compounds in biological signaling and briefly review their chemical properties and bioactivities in the context of the chronology of their discovery. Studies of the biological role of NO revealed why its chemistry is ideally suited for the tasks Nature has chosen for it; realising how the distinctive properties of sulfur can enrich this bioactivity does much to revive 'die Freude am experimentellen Spiel' of the pioneers in this field.
History, chemical properties and emerging biology of HSNO/SNO
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, SSNO
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and [ONN(O)-SO
3
]
2−
and their role in the sulfide/nitric oxide cross talk. |
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| Bibliography: | Martin Feelisch studied pharmacy and obtained his PhD degree from the Heinrich Heine University in 1988, working on mechanisms of guanylate cyclase stimulation by nitrovasodilators under the supervision of Professor Eike Noack. As Director of Pharmacology at Schwarz Pharma he led a drug discovery program on novel NO-donors before moving back to academia in 1997. After working with Salvador Moncada (University College London) he spent eight years in the US (LSU Shreveport and Boston University), returning to the UK in 2007 (Warwick University). In 2012 he was appointed as Professor of Experimental Medicine & Integrative Biology at the University of Southampton. His research interests are wide-ranging and include human adaptation to hypoxia, systems biology, and the redox chemistry of NO/HNO and sulfur species. Miriam Cortese-Krott was born in Milan (Italy) and obtained her Doctoral degree (Laurea) with honors in Pharmaceutical Biotechnology from the University of Milan in 2002. In 2006, she obtained a PhD in Pharmacology with honors from the Heinrich Heine University of Düsseldorf, working on nitric oxide biochemistry and biology under the supervision of Prof. Victoria Kolb-Bachofen. Later she worked on the chemistry and physiology of NO in erythrocytes with Prof. Malte Kelm. She won 4 Young Investigators' awards, and was an invited speaker at the NO-Gordon Research Conference. Since her Habilitation in Molecular Medicine, she is an independent Group Leader working on the NO/sulfide cross-talk in biology and cardiovascular medicine. Anthony Butler is a graduate of King's College, University of London. His PhD work was supervised by Victor Gold. After his graduation he worked at Northampton Technical College and then, on a post-doctoral fellowship, at Cornell University with Thomas Bruice. After a brief spell at the University of Sussex he moved to the University of St Andrews, where he worked in both the Chemistry Department and the Medical School. His main research interests included the chemistry of urea, iron-sulfur clusters, nitrosothiols and iron nitrosyls, the mechanism of nitration and nitrosylation reactions, and the physiology and medical use of nitric oxide. He is now retired. Derek Woollins was born in Cleethorpes and educated at the University of East Anglia (Norwich), where he went on to carry out his PhD. He was appointed as a lecturer at Imperial College London in 1982. After 12 years at Imperial College, he moved to Loughborough as the Chair in Inorganic Chemistry, where he stayed for 5 years before moving to St Andrews as the Chair in Synthetic Chemistry in 1999. He is currently Vice Principal (Research) and Provost at St Andrews. Woollins has published over 500 research papers in main group chemistry and three books. His research interests center around group 15/16 chemistry including the use of P-Se compounds (such as Woollins' Reagent) in synthesis and structural science. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1477-9226 1477-9234 |
| DOI: | 10.1039/c5dt05034k |