The Possible Role of Epigenetics in Gestational Diabetes: Cause, Consequence, or Both

Gestational diabetes mellitus (GDM) is defined as the glucose intolerance that is not present or recognized prior to pregnancy. Several risk factors of GDM depend on environmental factors that are thought to regulate the genome through epigenetic mechanisms. Thus, epigenetic regulation could be invo...

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Published inObstetrics and gynecology international Vol. 2010; no. 1; p. 605163
Main Authors Fernández-Morera, J. L., Rodríguez-Rodero, S., Menéndez-Torre, E., Fraga, M. F.
Format Journal Article
LanguageEnglish
Published United States Hindawi Publishing Corporation 01.01.2010
Wiley
Subjects
Review
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Summary:Gestational diabetes mellitus (GDM) is defined as the glucose intolerance that is not present or recognized prior to pregnancy. Several risk factors of GDM depend on environmental factors that are thought to regulate the genome through epigenetic mechanisms. Thus, epigenetic regulation could be involved in the development of GDM. In addition, the adverse intrauterine environment in patients with GDM could also have a negative impact on the establishment of the epigenomes of the offspring.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Julian T. Parer
ISSN:1687-9589
1687-9589
1687-9597
DOI:10.1155/2010/605163