Long-Term Outcomes after Multimodal Treatment for Clival Chordoma: Efficacy of the Endonasal Transclival Approach with Early Adjuvant Radiation Therapy

• Published in: Journal of clinical medicine Vol. 12; no. 13; p. 4460
• Main Authors: Yoo, Hyun Dong, Chung, Jong Chul, Park, Ki Seok, Chung, Seung Young, Park, Moon Sun, Ryu, Seungjun, Kim, Seong Min
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.07.2023; MDPI
• Subjects: Bone tumors; Care and treatment; Carotid arteries; Clinical medicine; Combined modality therapy; Endoscopy; Head and neck tumors; Health aspects; Magnetic resonance imaging; Medical prognosis; Methods; Patient outcomes; Patients; Radiation therapy; Radiotherapy; Sinuses; Skull base; Tumors; Tumors, Embryonal; South Korea; endonasal transclival approach; adjuvant radiation therapy; clival chorodma; skull base tumor
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12134460

This study investigates the long-term outcomes of clival chordoma patients treated with the endonasal transclival approach (ETCA) and early adjuvant radiation therapy. A retrospective review of 17 patients (2002-2013) showed a 10-year progression-free survival (PFS) rate of 67.4%, with the ETCA group showing fewer progressions and cranial neuropathies than those treated with combined approaches. The ETCA, a minimally invasive technique, provided a similar extent of resection compared to conventional skull-base approaches and enabled safe delivery of high-dose adjuvant radiotherapy. The findings suggest that ETCA is an effective treatment for centrally located clival chordomas.