Group 2 innate lymphoid cells in disease

Group 2 innate lymphoid cells (ILC2) are now recognized as an important innate source of type-2 effector cytokines. Although initially associated with mucosal tissues, it is clear that ILC2 are present in diverse anatomical locations. The function of ILC2 at these sites is equally varied, and althou...

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Bibliographic Details
Published inInternational immunology Vol. 28; no. 1; pp. 13 - 22
Main Author Halim, Timotheus Y F
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.01.2016
Subjects
Adaptive Immunity
Animals
Humans
Hypersensitivity - immunology
Immunity, Innate
Immunomodulation
Inflammation - immunology
Invited Review
Lymphocytes - immunology
Mucous Membrane - immunology
Th2 Cells - immunology
ILC2
allergies
type-2 inflammation
innate immunity
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Summary:Group 2 innate lymphoid cells (ILC2) are now recognized as an important innate source of type-2 effector cytokines. Although initially associated with mucosal tissues, it is clear that ILC2 are present in diverse anatomical locations. The function of ILC2 at these sites is equally varied, and although ILC2 represent a relatively minor population, they are fundamentally important regulators of innate and adaptive immune processes. As such, there is much interest to understand the role of ILC2 in diseases with a type-2 inflammatory component. This review explores the known roles of ILC2 in disease, and the diseases that show associations or other strong evidence for the involvement of ILC2.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0953-8178
1460-2377
DOI:10.1093/intimm/dxv050