The structure of the free radical produced from carcinogenic 4-hydroxyaminoquinoline 1-oxide

Abstract A potent carcinogen, 4-hydroxyaminoquinoline 1-oxide, was found to produce a stable free radical oxidatively. The structure of the free radical produced in dioxane was studied by analyizng the hyperfine structure of isotope-substituted 4-hydroxyaminoquinoline 1-oxides, and by comparing the...

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Bibliographic Details
Published inBulletin of the Chemical Society of Japan Vol. 40; no. 1; pp. 62 - 68
Main Authors Kataoka, N, Imamura, A, Kawazoe, Y, Chihara, G, Nagata, C
Format Journal Article
LanguageEnglish
Published Japan Chemical Society of Japan 01.01.1967
Subjects
Carcinogens
Chemical Phenomena
Chemistry
Quinolines
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Summary:Abstract A potent carcinogen, 4-hydroxyaminoquinoline 1-oxide, was found to produce a stable free radical oxidatively. The structure of the free radical produced in dioxane was studied by analyizng the hyperfine structure of isotope-substituted 4-hydroxyaminoquinoline 1-oxides, and by comparing the values of the spin densities obtained from the coupling constants with those calculated by the unrestricted SCF MO method. It was concluded that the free radical has the same molecular skeleton as the parent compound, but that it loses a hydrogen atom on the nitrogen atom of the NHOH group.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.40.62